Impedimetric antimicrobial peptide-based sensor for the early detection of periodontopathogenic bacteria

The aim of the present study was to combine the use of miniaturized and integrated impedimetric transducers and antimicrobial peptide AMPs to obtain biosensors with high sensitivity to monitor bacterial colonization to prevent implant-related infections.. Streptococcus sanguinis, which is one of the most prevalent strains in the onset of periodontal diseases, was used as a model of oral bacteria. To this end, a potent AMP derived from human lactoferrin was synthesized and covalently immobilized on interdigitated electrode arrays (IDEA). X-ray photoelectron spectroscopy (XPS) and electrochemical impedance spectroscopy (EIS) were employed to optimize and characterize the method of immobilization.
Biosensors and Bioelectronics, vol. 86, 2016, pp.377-385.