Articles científics destacats

Aquesta secció inclou una llista dels treballs científics més destacats de l'IMB-CNM publicats en revistes incloses al Science Citation Index (SCI), per any de publicació.

Monitoring of malolactic fermentation in wine using an electrochemical bienzymatic biosensor for L-lactate with long term stability

P. Giménez-Gómez et al.

The development of an amperometric biosensor for L-lactate determination showing long-term stability is reported in this work. The biosensor is based on a thin-film gold electrochemical transducer and a three-dimensional membrane of polypyrrole entrapping lactate oxidase and horseradish peroxidase enzymes. It was applied to monitor the malolactic fermentation of three red wines, showing a good agreement with the standard colorimetric method.
Anal. Chim. Acta 905 (2016) 126-133.

Implementing Thermometry on Silicon Surfaces Functionalized by Lanthanide-Doped Self-Assembled Polymer Monolayers

M. Rodrigues, et al.

Noncontact thermometric techniques with high-spatial resolution are essential for noninvasive off-chip characterization and heat management on Si surfaces. Here, the first ratiometric luminescent molecular thermometer implemented in a self-assembled polymer monolayer functionalized Si surface is reported.
Adv. Funct. Mater., 26: 200–209.

Resonant tunnelling features in a suspended silicon nanowire single-hole transistor

J. Llobet et al.

A suspended p-type Si nanowire incorporating Si nanocrystal quantum dots has been used to form a single-hole transistor. Fabrication is based on focused Ga ion beam exposure and anisotropic wet etching. Electrical characteristics at 10K show Coulomb diamonds with charging energy ~27 meV, associated with a single dominant nanocrystal.
Appl. Phys. Lett. 107, 223501 (2015)

Suspended Planar-Array Chips for Molecular Multiplexing at the Microscale

N. Torras et al.

A novel suspended planar-array chips technology is described, which effectively allows molecular multiplexing using a single suspended chip to analyze extraordinarily small volumes. The suspended chips are fabricated by combining silicon-based technology and polymer-pen lithography, obtaining increased molecular pattern flexibility, and improving miniaturization and parallel production. The chip miniaturization is so dramatic that it permits the intracellular analysis of living cells.
Adv. Mater. 2016, 28, 1449-1454

Fast determination of viable bacterial cells in milk samples using impedimetric sensor and a novel calibration method

N.Uria et al.

For development of an impedimetric biosensor to quantify viable bacterial cells, this work defines the relationships between microbial growth and impedance changes associated with acidification of the culture medium. Performed experiments demonstrated the capacity of the method to detect E.coli concentrations in a range between 10x2 and 10x6 cfu/mL in milk in only 6 hours with 5–12% error margin.
Electrochimica Acta, 198 (2016), pp. 249–258 .

Study From Cryogenic to High Temperatures of the High- and Low-Resistance-State Currents of ReRAM Ni–HfO2–Si Capacitors

C.Vaca et al.

Resistive switching conduction in Ni/HfO2/Si capacitors is studied at temperatures ranging from 77 to 473 K. A model for the low-resistance state (LRS) consistent with the experimental data is proposed. The LRS current–voltage curves show a maximum resistance, R0, at zero bias and a minimum value, R∞, at voltages close to reset, which indicates a departure from linearity. A three-parameter model for the I–V curves is reported and its temperature dependence analyzed.
IEEE Trans. Electron Devices 63 (5), pp. 1877-1883 (2016).

Polysilicon-chromium-gold intracellular chips for multi-functional biomedical applications

S.Durán et al.

In this work, the feasibility of using multi-material pSi-Cr-Au intracellular chips for multifunctional applications by characterizing their interactions with two different cell lines, one tumorigenic and one non-tumorigenic has been explored.
Nanoscale, 2016,8, 8773-8783

Multiple actuation microvalves in wax microfluidics

María Díaz-González et al.

A new type of electrically controlled and fully integrated wax microvalve is described in this work. The valve is designed for multiple actuation and has a small footprint (< 0.5 mm2), fast response (< 0.3 s) and low energy consumption (< 35 mJ).
Lab Chip, 2016,16, 3969-3976

Impedimetric antimicrobial peptide-based sensor for the early detection of periodontopathogenic bacteria

Mireia Hoyos-Nogués et al.

The aim of the present study was to combine the use of miniaturized and integrated impedimetric transducers and antimicrobial peptide AMPs to obtain biosensors with high sensitivity to monitor bacterial colonization to prevent implant-related infections.. Streptococcus sanguinis, which is one of the most prevalent strains in the onset of periodontal diseases, was used as a model of oral bacteria. To this end, a potent AMP derived from human lactoferrin was synthesized and covalently immobilized on interdigitated electrode arrays (IDEA). X-ray photoelectron spectroscopy (XPS) and electrochemical impedance spectroscopy (EIS) were employed to optimize and characterize the method of immobilization.
Biosensors and Bioelectronics, vol. 86, 2016, pp.377-385.

Solid contact ion sensor with conducting polymer layer copolymerized with the ion-selective membrane for determination of calcium in blood serum

Natalia Abramova et al.

A new solid contact ion selective electrode with intermediate conducting polymer (CP) layer formed by electropolymerization on a gold electrode of a bifunctional monomer, n-phenyl-ethylenediaminemethacrylamide (NPEDMA), which contains a methacrylamide group attached to aniline, is presented. Ion-selective membrane based on acrylated urethane polymer was shown to co-polymerize with the CP forming highly adhesive boundary. The designed ion-selective electrode was successfully used for determination of total calcium ion concentration in blood serum samples.
Analytica Chimica Acta, vol. 943, 2016, pp. 50-57.