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Ejercito de chips de silicio en forma de estrella sobre una población de células HeLa | CSIC.
Intracellular Mechanical Drugs Induce Cell-Cycle Altering and Cell Death
Arjona, M. I., Duch, M., Hernández-Pinto, A., Vázquez, P., Agusil, J. P., Gómez-Martínez, R., Redondo-Horcajo, M., Amirthalingam, E., Pérez-García, L., Suárez, T., Plaza, J. A.

Current advances in materials science have demonstrated that extracellular mechanical cues can define cell function and cell fate. However, a fundamental understanding of the manner in which intracellular mechanical cues affect cell mechanics remains elusive. How intracellular mechanical hindrance, reinforcement, and supports interfere with the cell cycle and promote cell death is described here. Reproducible devices with highly controlled size, shape, and with a broad range of stiffness are internalized in HeLa cells. Once inside, they induce characteristic cell-cycle deviations and promote cell death. Device shape and stiffness are the dominant determinants of mechanical impairment. Device structural support to the cell membrane and centering during mitosis maximize their effects, preventing spindle centering, and correct chromosome alignment. Nanodevices reveal that the spindle generates forces larger than 114 nN which overcomes intracellular confinement by relocating the device to a less damaging position. By using intracellular mechanical drugs, this work provides a foundation to defining the role of intracellular constraints on cell function and fate, with relevance to fundamental cell mechanics and nanomedicine.

Adv. Mater. 2022, 34, 2109581. https://doi.org/10.1002/adma.202109581

Detail of the microfluidic system, the tissue barrier and the hydrogel
Engineering Tissue Barrier Models on Hydrogel Microfluidic Platforms
Vera, D., García-Díaz, M., Torras, N., Álvarez, M., Villa, R., Martinez, E.

Tissue barriers play a crucial role in human physiology by establishing tissue compartmentalization and regulating organ homeostasis. Combining hydrogels with microfluidics technology provides unique opportunities to better recreate in vitro the tissue barrier models including the cellular components and the functionality of the in vivo tissues. Such platforms have the potential of greatly improving the predictive capacities of the in vitro systems in applications such as drug development, or disease modeling. Nevertheless, their development is not without challenges in their microfabrication. In this review, we will discuss the recent advances driving the fabrication of hydrogel microfluidic platforms and their applications in multiple tissue barrier models.

ACS Appl. Mater. Interfaces 2021, 13, 12, 13920–13933. https://doi.org/10.1021/acsami.0c21573

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