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Invited IMB-CNM Talk: Single molecule detection in nanofluidic devices


07 Oct 2022

Invited IMB-CNM Talk: Single molecule detection in nanofluidic devices

Single molecule detection is one of the main challenges in biosensing. But it requires devices capable of  manipulating minute amounts of liquid and the (bio)molecules inside, and ultra-high sensitivity read-out techniques to record the molecular information.

In our group we use all-transparent, all-plastic single-use nanofluidic devices with multidimensional components to filter, control and bring the liquid into sub-100 nm nanochannels. They can be used to analyse DNA molecules, which can be barcoded to obtain their genomic information. As additional functionalities, we can also integrate the nanochannels with plasmonic bowtie antennas. In this case, the bowties can nano-focus the light spot beyond diffraction. Furthermore, we can also integrate suspended structures into the devices, like suspended nano channels or membranes, to be used as mechanical resonators.

About Irene Fernández-Cuesta

I did my PhD at CNM in Barcelona in 2009, where I learned about micro and nano fabrication, and working with nanodevices. Then, I moved to the Technical University of Denmark, where I got a Marie Curie IOF, and started working with DNA. I then spent fours years in Berkeley, working with nanofluidics and plasmonics, and where I started a company. Since 2014 Im a group leader at the University of Hamburg, where we focus on using the nano devices for single biomolecule analysis.