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Scientific Highlights

This section includes a list of the highlighted IMB-CNM scientific papers published in journals included in the Science Citation Index (SCI), per year of publication.

Multidimensional Anisotropic Architectures on Polymeric Microparticles
J.P. Agusil, M.I. Arjona, M. Duch, N. Fusté, J.A. Plaza

Next generation technologies will require Multidimensional Anisotropic Architectures with tunable physical and chemical intraparticle building blocks combination to meet the demands of high throughput and multiplexing. Here, we report a strategy to integrate a vast number of anisotropic dimensions combining polymer photolithography with (bio)chemical modifications via soft lithography. Our work allows a combination of microparticle traits in a 15-dimensional anisotropic space at the micrometric scale. No current technology provides these degrees of physical, chemical, surface coverage, and surface pattern anisotropies, which can be used interchangeably or in combination; obtaining an innumerable number of engineering microparticles with barcoding capabilities.
Small 2020, 2004691, doi: 10.1002/smll.202004691

Technological development of intracellular polysilicon-chromium-gold chips for orthogonal chemical functionalization
S. Durán et al.

Taking advantage of the ability of microelectronics to manufacture devices under cell dimensions and a large variety of features, we report a technology for the fabrication of multi-material chips as bi-functional cell-internalizable devices. These microtools have a promising future as intracellular functional platforms for biosensing, diagnosis and drug delivery.
Sensors and Actuators B. Chemical, 209, 212-224 (2015)

Increasing the eleastic modulus of graphene by controlled defect creation
Guillermo López-Polín et al.

The presence of lattice defects in graphene might degrade its mechanical properties. We report a study on the elastic modulus and strength with a controlled density of defects. Counter-intuitively, the in-plane Young’s modulus increases with defect density up to 2x the initial value for a vacancy content of ~0.2%.
Nature Physics 11, 26–31 (2015) 

Silicon-nanowire based attachment of silicon chips for mouse embryo labelling
S. Durán et al.

The adhesion of small silicon chips to cells has many potential applications as direct interconnection of the cells to the external world can be accomplished. Although some typical applications of silicon nanowires integrated into microsystems are focused on achieving a cell-on-a-chip strategy, we are interested in obtaining chip-on-a-cell systems. This paper reports the design, technological development and characterization of polysilicon barcodes featuring silicon nanowires as nanoscale attachment to identify and track living mouse embryos during their in vitro development.
Lab on a Chip, 15, 1508-1514 (2015)

Dual chronoamperometric detection of enzymatic biomarkers using magnetic beads and a low-cost flow cell
J. Moral-Vico et al.

We report on the production of a low cost microfluidic device for the multiplexed electrochemical detection of magneto bioassays. As a proof of concept, the device has been used to detect Myeloperoxidase (MPO), a cardiovascular biomarker. A dual MPO mass and activity assay has been finally applied to the study of 10 real plasma samples, allowing patient classification according to the risk of suffering a cardiovascular event.
Biosensors and Bioelectronics 69, 328–336 (2015) 

Thermal Analysis of LED Lamps for Optimal Driver Integration
X. Perpiñà et al.

This work reports on the thermal influence of an LED (Light Emitting Diode) driver on a retrofit LED lamp, also reporting on a procedure for its thermal characterization and multi-scale modeling to optimise its integration. This study has been carried out within the Consumerizing Solid State Lighting project led by Philips and funded by ENIAC Joint Undertaking platform. 

Biofunctionalized all-polymer photonic lab on a chip with integrated solid-state light emitter
A.Llobera et al.

A photonic lab on a chip (PhLOC), comprising a solid-state light emitter (SSLE) aligned with a biofunctionalized optofluidic multiple internal reflection (MIR) system, is presented. The SSLE is obtained by filling a microfluidic structure with a phenyltrimethoxysilane (PhTMOS) aqueous sol solution containing a fluorophore organic dye. Its performance is assessed by measuring quinolone yellow, obtaining a limit of detection (LOD) of (0.60±0.01) µM. Finally, the MIR is selectively biofunctionalized with horseradish peroxidase (HRP) for the detection of hydrogen peroxide (H2O2) target analyte, obtaining a LOD of (0.7±0.1) µM for H2O2.
Light: Science & Applications (2015) 4, e271; DOI:10.1038/lsa.2015.44 

Nanoscale reduction of graphene oxide thin films and its characterization
M. Lorenzoni et al.

In this paper, we report on a method to reduce thin films of graphene oxide (GO) to a spatial resolution better than 100 nm over several tens of micrometers by means of an electrochemical scanning probe based lithography.
Nanotechnology 26 (2015) 285301.

Functional and Consumption Analysis of Integrated Circuits Supplied by Inductive Power Transfer by Powering Modulation and Lock-in Infrared Imaging
J. León, et al.

The functionality and consumption of an RFID IC supplied by Inductive Power Transfer (IPT) has been non-invasively analyzed by IR thermography.The main aspects addressed in thiswork have been: the suitability study of the proposed modulation strategies, the characterization of the coupling between coils and its effects on the RFID blocks, the RFID IC functional analysis, and the dependence of the local energy consumption on the total power delivered to the die.
IEEE Transactions on Industrial Electronics

A microfluidic device for the automated electrical readout of low-density glass-slide microarrays
María Díaz-González, et al.

In this work an automated and reusable electrical readout system for low-cost glass slide microarrays is described. The system, which enabled the simultaneous conductimetric detection of up to 36 biorecognition events, comprises an array of interdigitated electrode transducers and a polydimethylsiloxane microfluidic structure, aligned over it.
The impedimetric system shows similar sensitivity to that of fluorescence scanners.
Biosensors and Bioelectronics 74 (2015) 698–704.