Institute of Microelectronics of Barcelona IMB-CNM   

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The research activities of the Biomedical Applications Group (GAB) takes advantage of the technological capacities available at the Clean Room of the IMB-CNM in order to provide novel solutions to different biomedical applications. These solutions are mainly based on impedance sensing at different levels of biological organization, i.e. mollecules, cells and organs. As a consequence, the group works jointly with different biomedical research groups, from the theoretical analysis to the final clinical trials. Specifically, the group is interested in three major topics:

Biosensors

Study and development of new technologies and strategies to fabricate electrochemical immunosensors based on impedimetric transduction in order to improve and optimize its direct response to different biomarkers.

Fabrication of microtechnology-based smart devices in both, silicon and flexible materials, for online biofilm monitoring including different sensors (impedance, pH, dissolved oxygen and ion concentration).

Development of flexible sensing devices to evaluate the corneal barrier function in a non-invasive way by measuring the bioimpedance changes of the different corneal layers.

Neuroscience

The need of micro- and nanosystems for in vivo and in vitro neurophisilogical studies is an incipient topic which is of special interest for our group. Stimulation and recording microelectrodes, where their recording quality mainly depends on their impedances, are being used for these purposes. Research is divided in developing new microsystem designs, and new microelectrode materials or surface in order to improve the contact of the electrode-electrolyte interface.

Fabrication of Multielectrode arrays (MEAs) to monitor cell cultures of neural cells to fulfill the interests of different neural research groups. Development of different technological processes for the fabrication of microelectrodes on flexible substrates capable to adapt to the brain surface.

Collaboration in the fabrication of flexible multisensor microneedles where microfluidic channels have been integrated for in vivo neural experimentation.

Study of the use of graphene as an electrode material to improve the sensitivity of both neural register and stimulating electrodes.

Organ-on-a-chip

Innovative in vitro microfluidic models give the opportunity to mimic complex organ physiology in a laboratory allowing the study and development of medical treatments. In collaboration with different biomedical groups, we are developing new biotechnological platforms to facilitate the cell co-cultures performed under real-like conditions and its monitoring.

Liver-on-a-chip. Design and development of a 3D cell culture modular bioreactor that mimics the interior of the hepatic sinusoid to study different liver diseases (hepatitis, hepatocellular carcinoma, cirrhosis, etc.), and developing personalized therapies using liver cells obtained from patients.

Develpment and fabrication of a biotechnological platform that integrate advanced monitoring technologies to assess the barrier function of the Blood Brain and Blood Retinal Barriers.

More info at the GAB webpage.

   
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