Lanthanide Luminescence to Mimic Molecular Logic and Computing through Physical Inputs; M. A. Hernández‐Rodríguez, et al; Adv. Optical Mater. 2020, 2000312..The remarkable advances in molecular logic reported in the last decade demonstrate the potential of luminescent molecules for logical operations, a paradigm-changing concerning silicon-based electronics. Trivalent lanthanide (Ln3+) ions, with their characteristic narrow line emissions, long-lived excited states, and photostability under illumination, may improve the state-of-the-art molecular logical devices. Here, the use of monolithic silicon-based structures incorporating Ln3+ complexes for performing logical functions is reported. Contrary to chemical inputs, physical inputs may enable the future concatenation of distinct logical functions and reuse of the logical devices, a clear step forward toward input–output homogeneity that is precluding the integration of nowadays molecular logic devices.
A self-calibrating and multiplexed electrochemical lab-on-a-chip for cell culture analysis and high-resolution imaging; Pablo Giménez-Gómez et al.; Lab Chip, 2020, Advance Article.This paper presents a new tool that allows a self-calibrating and multiplexed electrochemical lab-on-a-chip (ME-LoC) for cell culture analysis and high-resolution imaging. The ME-LoC contains a complex network of micro-channels and micro-chambers that allow compartmentalization of the reference electrode; cell seeding and proliferation without biofouling; electrode reactivation and recalibration; and multiple analyte detection, namely glucose and hydrogen peroxide concentrations, conductivity and ORP, as a way to monitor cell metabolism. Electrochemical analysis is completed with high-resolution imaging after labelling with fluorescent dyes. For its simplicity, integration, automation, compartmentalisation and microfluidic control, thist technology is a promising alternative for in vitro testing and organ-on-a-chip development in the near future.